A Genome-Wide Association Study Identifies Susceptibility Loci for Ovarian Cancer at 2q31 and 8q24

Ovarian cancer (OC) accounts for more deaths than all other gynecological cancers combined. To identify common low-penetrance OC susceptibility genes, we conducted a genome-wide association study (GWAS) of 507,094 SNPs in 1,768 cases and 2,354 controls, with follow-up of 21,955 SNPs in 4,162 cases a...

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Autori principali: Goode, Ellen L., Chenevix-Trench, Georgia, Song, Honglin, Ramus, Susan J., Notaridou, Maria, Lawrenson, Kate, Widschwendter, Martin, Vierkant, Robert A., Larson, Melissa C., Kjaer, Susanne K., Birrer, Michael J., Berchuck, Andrew, Schildkraut, Joellen, Tomlinson, Ian, Kiemeney, Lambertus A., Cook, Linda S., Gronwald, Jacek, Garcia-Closas, Montserrat, Gore, Martin E., Campbell, Ian, Whittemore, Alice S., Sutphen, Rebecca, Phelan, Catherine, Anton-Culver, Hoda, Pearce, Celeste Leigh, Lambrechts, Diether, Rossing, Mary Anne, Chang-Claude, Jenny, Moysich, Kirsten B., Goodman, Marc T., Dörk, Thilo, Nevanlinna, Heli, Ness, Roberta B., Rafnar, Thorunn, Hogdall, Claus, Hogdall, Estrid, Fridley, Brooke L., Cunningham, Julie M., Sieh, Weiva, McGuire, Valerie, Godwin, Andrew K., Cramer, Daniel W., Hernandez, Dena, Levine, Douglas, Lu, Karen, Iversen, Edwin S., Palmieri, Rachel T., Houlston, Richard, van Altena, Anne M., Aben, Katja K.H., Massuger, Leon F.A.G., Brooks-Wilson, Angela, Kelemen, Linda E., Le, Nhu D., Jakubowska, Anna, Lubinski, Jan, Medrek, Krzysztof, Stafford, Anne, Easton, Douglas F., Tyrer, Jonathan, Bolton, Kelly L., Harrington, Patricia, Eccles, Diana, Chen, Ann, Molina, Ashley N., Davila, Barbara N., Arango, Hector, Tsai, Ya-Yu, Chen, Zhihua, Risch, Harvey A., McLaughlin, John, Narod, Steven A., Ziogas, Argyrios, Brewster, Wendy, Gentry-Maharaj, Aleksandra, Menon, Usha, Wu, Anna H., Stram, Daniel O., Pike, Malcolm C., Beesley, Jonathan, Webb, Penelope M., Chen, Xiaoqing, Ekici, Arif B., Thiel, Falk C., Beckmann, Matthias W., Yang, Hannah, Wentzensen, Nicolas, Lissowska, Jolanta, Fasching, Peter A., Despierre, Evelyn, Amant, Frederic, Vergote, Ignace, Doherty, Jennifer, Hein, Rebecca, Wang-Gohrke, Shan, Lurie, Galina, Carney, Michael E., Thompson, Pamela J., Runnebaum, Ingo, Hillemanns, Peter, Dürst, Matthias, Antonenkova, Natalia, Bogdanova, Natalia, Leminen, Arto, Butzow, Ralf, Heikkinen, Tuomas, Stefansson, Kari, Sulem, Patrick, Besenbacher, Sören, Sellers, Thomas A., Gayther, Simon A., Pharoah, Paul D.P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3020231/
https://ncbi.nlm.nih.gov/pubmed/20852632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.668
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