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Mechanisms underlying losses of heterozygosity in human colorectal cancers

Losses of heterozygosity are the most common molecular genetic alteration observed in human cancers. However, there have been few systematic studies to understand the mechanism(s) responsible for losses of heterozygosity in such tumors. Here we report a detailed investigation of the five chromosomes...

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Hlavní autoři: Thiagalingam, Sam, Laken, Steve, Willson, James K. V., Markowitz, Sanford D., Kinzler, Kenneth W., Vogelstein, Bert, Lengauer, Christoph
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences 2001
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC30201/
https://ncbi.nlm.nih.gov/pubmed/11226302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.051625398
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