Mechanisms underlying losses of heterozygosity in human colorectal cancers

Losses of heterozygosity are the most common molecular genetic alteration observed in human cancers. However, there have been few systematic studies to understand the mechanism(s) responsible for losses of heterozygosity in such tumors. Here we report a detailed investigation of the five chromosomes...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Thiagalingam, Sam, Laken, Steve, Willson, James K. V., Markowitz, Sanford D., Kinzler, Kenneth W., Vogelstein, Bert, Lengauer, Christoph
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2001
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC30201/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11226302/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.051625398
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