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Mechanisms underlying losses of heterozygosity in human colorectal cancers

Losses of heterozygosity are the most common molecular genetic alteration observed in human cancers. However, there have been few systematic studies to understand the mechanism(s) responsible for losses of heterozygosity in such tumors. Here we report a detailed investigation of the five chromosomes...

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Autori principali: Thiagalingam, Sam, Laken, Steve, Willson, James K. V., Markowitz, Sanford D., Kinzler, Kenneth W., Vogelstein, Bert, Lengauer, Christoph
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 2001
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC30201/
https://ncbi.nlm.nih.gov/pubmed/11226302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.051625398
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