Targeted deletion of Smad4 shows it is required for transforming growth factor β and activin signaling in colorectal cancer cells

Smad4 (DPC4) is a candidate tumor suppressor gene that has been hypothesized to be critical for transmitting signals from transforming growth factor (TGF) β and related ligands. To directly test this hypothesis, the Smad4 gene was deleted through homologous recombination in human colorectal cancer c...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Zhou, Shibin, Buckhaults, Phillip, Zawel, Leigh, Bunz, Fred, Riggins, Greg, Le Dai, Jia, Kern, Scott E., Kinzler, Kenneth W., Vogelstein, Bert
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1998
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC19358/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9482899/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.5.2412
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