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Safety and Pharmacokinetics of IDX184, a Liver-Targeted Nucleotide Polymerase Inhibitor of Hepatitis C Virus, in Healthy Subjects

IDX184 is a nucleotide prodrug designed to enhance formation in the liver of the active triphosphate of 2′-methylguanosine (2′-MeG), a potent and specific polymerase inhibitor of the hepatitis C virus (HCV). In the present study, single ascending oral doses of 5, 10, 25, 50, 75, and 100 mg IDX184 we...

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Autors principals: Zhou, Xiao-Jian, Pietropaolo, Keith, Chen, Jie, Khan, Samina, Sullivan-Bólyai, John, Mayers, Douglas
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3019633/
https://ncbi.nlm.nih.gov/pubmed/21060109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01101-10
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