Single-Dose Escalation and Multiple-Dose Safety, Tolerability, and Pharmacokinetics of IDX899, a Candidate Human Immunodeficiency Virus Type 1 Nonnucleoside Reverse Transcriptase Inhibitor, in Healthy Subjects

IDX899 is a novel nonnucleoside reverse transcriptase inhibitor (NNRTI) with potent in vitro activity against wild-type and NNRTI-resistant strains of human immunodeficiency virus type 1 (HIV-1) and with a high genetic barrier to resistance. Single rising doses of 50 and 100 (given by use of a 50-mg...

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Detalhes bibliográficos
Main Authors: Zhou, Xiao-Jian, Pietropaolo, Keith, Damphousse, David, Belanger, Bruce, Chen, Jie, Sullivan-Bólyai, John, Mayers, Douglas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2681571/
https://ncbi.nlm.nih.gov/pubmed/19223643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01479-08
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