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Rational Dose Selection for a Nonnucleoside Reverse Transcriptase Inhibitor through Use of Population Pharmacokinetic Modeling and Monte Carlo Simulation

In order to choose a rational dose for GW 420867X, we first set a goal of therapy. We hypothesized that, for optimal antiretroviral activity, the trough free drug concentration should remain above the 90% effective concentration (EC(90)) of human immunodeficiency virus type 1. We performed populatio...

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Detalhes bibliográficos
Main Authors: Drusano, G. L., Moore, K. H. P., Kleim, J. P., Prince, W., Bye, A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC127507/
https://ncbi.nlm.nih.gov/pubmed/11850287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.3.913-916.2002
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