First-in-Human Study of the Pharmacokinetics and Antiviral Activity of IDX375, a Novel Nonnucleoside Hepatitis C Virus Polymerase Inhibitor

IDX375 is a potent and selective palm-binding nonnucleoside inhibitor of the hepatitis C virus (HCV) genotype 1 polymerase. This first-in-human study evaluated the safety, tolerability, and pharmacokinetics of IDX375 in healthy volunteers, as well as its antiviral activity in HCV-infected patients....

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Detalhes bibliográficos
Main Authors: de Bruijne, J., van de Wetering de Rooij, J., van Vliet, A. A., Zhou, X. J., Temam, M. F., Molles, J., Chen, J., Pietropaolo, K., Sullivan-Bólyai, J. Z., Mayers, D., Reesink, H. W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421546/
https://ncbi.nlm.nih.gov/pubmed/22664976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00451-12
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