Safety, Pharmacokinetics, and Antiviral Activity of AT-527, a Novel Purine Nucleotide Prodrug, in Hepatitis C Virus-Infected Subjects with or without Cirrhosis

AT-527 is a novel modified guanosine nucleotide prodrug inhibitor of the hepatitis C virus (HCV) NS5B polymerase, with increased in vitro antiviral activity compared to sofosbuvir and a highly differentiated favorable preclinical profile compared to other anti-HCV nucleoside/nucleotide analogs. This...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Berliba, Elina, Bogus, Maxim, Vanhoutte, Frédéric, Berghmans, Pieter-Jan, Good, Steven S., Moussa, Adel, Pietropaolo, Keith, Murphy, Robert L., Zhou, Xiao-Jian, Sommadossi, Jean-Pierre
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6879261/
https://ncbi.nlm.nih.gov/pubmed/31570394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01201-19
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