Characterization of SMG-9, an essential component of the nonsense-mediated mRNA decay SMG1C complex

SMG-9 is part of a protein kinase complex, SMG1C, which consists of the SMG-1 kinase, SMG-8 and SMG-9. SMG1C mediated phosphorylation of Upf1 triggers nonsense-mediated mRNA decay (NMD), a eukaryotic surveillance pathway that detects and targets for degradation mRNAs harboring premature translation...

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Hlavní autoři: Fernández, Israel S., Yamashita, Akio, Arias-Palomo, Ernesto, Bamba, Yumi, Bartolomé, Ruben A., Canales, M. Angeles, Teixidó, Joaquín, Ohno, Shigeo, Llorca, Oscar
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2011
Témata:
Structural Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3017601/
https://ncbi.nlm.nih.gov/pubmed/20817927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq749
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