An isolated, surface-expressed I domain of the integrin αLβ2 is sufficient for strong adhesive function when locked in the open conformation with a disulfide bond

We introduced disulfide bonds to lock the integrin αLβ2 I domain in predicted open, ligand binding or closed, nonbinding conformations. Transfectants expressing αLβ2 heterodimers containing locked-open but not locked-closed or wild-type I domains constitutively adhered to intercellular adhesion mole...

ver descrição completa

Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Lu, Chafen, Shimaoka, Motomu, Ferzly, Mazen, Oxvig, Claus, Takagi, Junichi, Springer, Timothy A.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2001
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC30148/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11226249/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.041606398
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!