An isolated, surface-expressed I domain of the integrin αLβ2 is sufficient for strong adhesive function when locked in the open conformation with a disulfide bond

We introduced disulfide bonds to lock the integrin αLβ2 I domain in predicted open, ligand binding or closed, nonbinding conformations. Transfectants expressing αLβ2 heterodimers containing locked-open but not locked-closed or wild-type I domains constitutively adhered to intercellular adhesion mole...

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Publicado en:	Proc Natl Acad Sci U S A
Autores principales:	Lu, Chafen, Shimaoka, Motomu, Ferzly, Mazen, Oxvig, Claus, Takagi, Junichi, Springer, Timothy A.
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	National Academy of Sciences 2001
Materias:	Biological Sciences
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC30148/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11226249/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.041606398
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