A Copper Chelate of Thiosemicarbazone NSC 689534 induces Oxidative/ER Stress and Inhibits Tumor Growth In Vitro and In Vivo

In this study, a Cu(2+) chelate of the novel thiosemicarbazone NSC 689534 was evaluated for in vitro and in vivo anti-cancer activity. Results demonstrated that NSC 689534 activity (low µM range) was enhanced 4–5 fold by copper chelation and completely attenuated by iron. Importantly, once formed, t...

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Hauptverfasser: Hancock, Chad N., Stockwin, Luke H., Han, Bingnan, Divelbiss, Raymond D., Jun, Jung Ho, Malhotra, Sanjay V., Hollingshead, Melinda G., Newton, Dianne L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3014388/
https://ncbi.nlm.nih.gov/pubmed/20971185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2010.10.696
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