Bis-Halogen-Anthraniloyl-Substituted Nucleoside 5′-Triphosphates as Potent and Selective Inhibitors of Bordetella pertussis Adenylyl Cyclase Toxin

Whooping cough is caused by Bordetella pertussis and still constitutes one of the top five causes of death in young children, particularly in developing countries. The calmodulin-activated adenylyl cyclase (AC) toxin CyaA substantially contributes to disease development. Thus, potent and selective C...

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Main Authors: Geduhn, Jens, Dove, Stefan, Shen, Yuequan, Tang, Wei-Jen, König, Burkhard, Seifert, Roland
Formato: Artigo
Idioma:Inglês
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2011
Assuntos:
Drug Discovery and Translational Medicine
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3014302/
https://ncbi.nlm.nih.gov/pubmed/20962032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.174219
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