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Structural basis for the interaction of Bordetella pertussis adenylyl cyclase toxin with calmodulin

CyaA is crucial for colonization by Bordetella pertussis, the etiologic agent of whooping cough. Here we report crystal structures of the adenylyl cyclase domain (ACD) of CyaA with the C-terminal domain of calmodulin. Four discrete regions of CyaA bind calcium-loaded calmodulin with a large buried c...

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Bibliografski detalji
Glavni autori: Guo, Qing, Shen, Yuequan, Lee, Young-Sam, Gibbs, Craig S, Mrksich, Milan, Tang, Wei-Jen
Format: Artigo
Jezik:Inglês
Izdano: 2005
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1224690/
https://ncbi.nlm.nih.gov/pubmed/16138079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600800
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