Allosteric Activation of Bordetella pertussis Adenylyl Cyclase by Calmodulin: MOLECULAR DYNAMICS AND MUTAGENESIS STUDIES

Adenylyl cyclase (AC) toxin is an essential toxin that allows Bordetella pertussis to invade eukaryotic cells, where it is activated after binding to calmodulin (CaM). Based on the crystal structure of the AC catalytic domain in complex with the C-terminal half of CaM (C-CaM), our previous molecular...

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Autores principales: Selwa, Edithe, Davi, Marilyne, Chenal, Alexandre, Sotomayor-Pérez, Ana-Cristina, Ladant, Daniel, Malliavin, Thérèse E.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Molecular Biophysics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4110316/
https://ncbi.nlm.nih.gov/pubmed/24907274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.530410
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