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Bioengineering of Bordetella pertussis Adenylate Cyclase Toxin for Antigen-Delivery and Immunotherapy

The adenylate cyclase toxin (CyaA) is one of the major virulence factors of Bordetella pertussis, the causative agent of whooping cough. CyaA is able to invade eukaryotic cells where, upon activation by endogenous calmodulin, it synthesizes massive amounts of cAMP that alters cellular physiology. Th...

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Detaylı Bibliyografya
Yayımlandı:Toxins (Basel)
Asıl Yazarlar: Chenal, Alexandre, Ladant, Daniel
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: MDPI 2018
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6070788/
https://ncbi.nlm.nih.gov/pubmed/30037010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins10070302
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