Suppression of T-Lymphocyte Activation and Chemotaxis by the Adenylate Cyclase Toxin of Bordetella pertussis

The adenylate cyclase toxin (CyaA) released by Bordetella pertussis is an essential virulence factor for colonization of the host. This toxin inhibits migration and activation of phagocytes, thereby preventing bacterial killing. In addition, CyaA interferes with the initiation of adaptive immunity b...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Paccani, Silvia Rossi, Molin, Federica Dal, Benagiano, Marisa, Ladant, Daniel, D'Elios, Mario M., Montecucco, Cesare, Baldari, Cosima T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2008
Schlagworte:
Molecular Pathogenesis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2446734/
https://ncbi.nlm.nih.gov/pubmed/18426886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00200-08
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