Suppression of T-Lymphocyte Activation and Chemotaxis by the Adenylate Cyclase Toxin of Bordetella pertussis

The adenylate cyclase toxin (CyaA) released by Bordetella pertussis is an essential virulence factor for colonization of the host. This toxin inhibits migration and activation of phagocytes, thereby preventing bacterial killing. In addition, CyaA interferes with the initiation of adaptive immunity b...

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Bibliografiske detaljer
Main Authors: Paccani, Silvia Rossi, Molin, Federica Dal, Benagiano, Marisa, Ladant, Daniel, D'Elios, Mario M., Montecucco, Cesare, Baldari, Cosima T.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2008
Fag:
Molecular Pathogenesis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2446734/
https://ncbi.nlm.nih.gov/pubmed/18426886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00200-08
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