The Adenylate Cyclase Toxins of Bacillus anthracis and Bordetella pertussis Promote Th2 Cell Development by Shaping T Cell Antigen Receptor Signaling

The adjuvanticity of bacterial adenylate cyclase toxins has been ascribed to their capacity, largely mediated by cAMP, to modulate APC activation, resulting in the expression of Th2–driving cytokines. On the other hand, cAMP has been demonstrated to induce a Th2 bias when present during T cell primi...

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Bibliografiske detaljer
Main Authors: Rossi Paccani, Silvia, Benagiano, Marisa, Capitani, Nagaja, Zornetta, Irene, Ladant, Daniel, Montecucco, Cesare, D'Elios, Mario M., Baldari, Cosima T.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2009
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643477/
https://ncbi.nlm.nih.gov/pubmed/19266022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000325
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