Interactions of Bordetella pertussis adenylyl cyclase toxin CyaA with calmodulin mutants and calmodulin antagonists: Comparison with membranous adenylyl cyclase I

The adenylyl cyclase (AC) toxin CyaA from Bordetella pertussis constitutes an important virulence factor for the pathogenesis of whooping cough. CyaA is activated by calmodulin (CaM) and compromises host defense by excessive cAMP production. Hence, pharmacological modulation of the CyaA/CaM interact...

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Main Authors: Schuler, Dominik, Lübker, Carolin, Lushington, Gerald H., Tang, Wei-Jen, Shen, Yuequan, Richter, Mark, Seifert, Roland
格式: Artigo
語言:Inglês
出版: 2012
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3915356/
https://ncbi.nlm.nih.gov/pubmed/22265637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2012.01.005
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