Interactions of Bordetella pertussis adenylyl cyclase toxin CyaA with calmodulin mutants and calmodulin antagonists: Comparison with membranous adenylyl cyclase I

The adenylyl cyclase (AC) toxin CyaA from Bordetella pertussis constitutes an important virulence factor for the pathogenesis of whooping cough. CyaA is activated by calmodulin (CaM) and compromises host defense by excessive cAMP production. Hence, pharmacological modulation of the CyaA/CaM interact...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Schuler, Dominik, Lübker, Carolin, Lushington, Gerald H., Tang, Wei-Jen, Shen, Yuequan, Richter, Mark, Seifert, Roland
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2012
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3915356/
https://ncbi.nlm.nih.gov/pubmed/22265637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2012.01.005
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