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Physiological calcium concentrations regulate calmodulin binding and catalysis of adenylyl cyclase exotoxins
Edema factor (EF) and CyaA are calmodulin (CaM)-activated adenylyl cyclase exotoxins involved in the pathogenesis of anthrax and whooping cough, respectively. Using spectroscopic, enzyme kinetic and surface plasmon resonance spectroscopy analyses, we show that low Ca(2+) concentrations increase the...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC139101/ https://ncbi.nlm.nih.gov/pubmed/12485993 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf681 |
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