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Physiological calcium concentrations regulate calmodulin binding and catalysis of adenylyl cyclase exotoxins

Edema factor (EF) and CyaA are calmodulin (CaM)-activated adenylyl cyclase exotoxins involved in the pathogenesis of anthrax and whooping cough, respectively. Using spectroscopic, enzyme kinetic and surface plasmon resonance spectroscopy analyses, we show that low Ca(2+) concentrations increase the...

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Bibliografische gegevens
Hoofdauteurs: Shen, Yuequan, Lee, Young-Sam, Soelaiman, Sandriyana, Bergson, Pamela, Lu, Dan, Chen, Alice, Beckingham, Kathy, Grabarek, Zenon, Mrksich, Milan, Tang, Wei-Jen
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2002
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC139101/
https://ncbi.nlm.nih.gov/pubmed/12485993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf681
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