Physiological calcium concentrations regulate calmodulin binding and catalysis of adenylyl cyclase exotoxins

Edema factor (EF) and CyaA are calmodulin (CaM)-activated adenylyl cyclase exotoxins involved in the pathogenesis of anthrax and whooping cough, respectively. Using spectroscopic, enzyme kinetic and surface plasmon resonance spectroscopy analyses, we show that low Ca(2+) concentrations increase the...

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Pubblicato in:	EMBO J
Autori principali:	Shen, Yuequan, Lee, Young-Sam, Soelaiman, Sandriyana, Bergson, Pamela, Lu, Dan, Chen, Alice, Beckingham, Kathy, Grabarek, Zenon, Mrksich, Milan, Tang, Wei-Jen
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Publishing Group 2002
Soggetti:	Articles
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC139101/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12485993/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdf681
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