Development of a Selective Small-Molecule Inhibitor of Kir1.1, the Renal Outer Medullary Potassium Channel

The renal outer medullary potassium (K(+)) channel, ROMK (Kir1.1), is a putative drug target for a novel class of loop diuretic that would lower blood volume and pressure without causing hypokalemia. However, the lack of selective ROMK inhibitors has hindered efforts to assess its therapeutic potent...

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Main Authors: Bhave, Gautam, Chauder, Brian A., Liu, Wen, Dawson, Eric S., Kadakia, Rishin, Nguyen, Thuy T., Lewis, L. Michelle, Meiler, Jens, Weaver, C. David, Satlin, Lisa M., Lindsley, Craig W., Denton, Jerod S.
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Pharmacology and Experimental Therapeutics 2011
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3014278/
https://ncbi.nlm.nih.gov/pubmed/20926757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.110.066928
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