Metabolites from apoptotic thymocytes inhibit thymopoiesis in adenosine deaminase–deficient fetal thymic organ cultures

Murine fetal thymic organ culture was used to investigate the mechanism by which adenosine deaminase (ADA) deficiency causes T-cell immunodeficiency. C57BL/6 fetal thymuses treated with the specific ADA inhibitor 2′-deoxycoformycin exhibited features of the human disease, including accumulation of d...

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Detaylı Bibliyografya

Yayımlandı:	J Clin Invest
Asıl Yazarlar:	Thompson, Linda F., Van De Wiele, C. Justin, Laurent, Aletha B., Hooker, Scott W., Vaughn, James G., Jiang, Hong, Khare, Kamayani, Kellems, Rodney E., Blackburn, Michael R., Hershfield, Michael S., Resta, Regina
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	American Society for Clinical Investigation 2000
Konular:	Article
Online Erişim:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC301416/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11067867/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI9944
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