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Metabolites from apoptotic thymocytes inhibit thymopoiesis in adenosine deaminase–deficient fetal thymic organ cultures

Murine fetal thymic organ culture was used to investigate the mechanism by which adenosine deaminase (ADA) deficiency causes T-cell immunodeficiency. C57BL/6 fetal thymuses treated with the specific ADA inhibitor 2′-deoxycoformycin exhibited features of the human disease, including accumulation of d...

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Udgivet i:J Clin Invest
Principais autores: Thompson, Linda F., Van De Wiele, C. Justin, Laurent, Aletha B., Hooker, Scott W., Vaughn, James G., Jiang, Hong, Khare, Kamayani, Kellems, Rodney E., Blackburn, Michael R., Hershfield, Michael S., Resta, Regina
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2000
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC301416/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11067867/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI9944
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