Metabolites from apoptotic thymocytes inhibit thymopoiesis in adenosine deaminase–deficient fetal thymic organ cultures

Murine fetal thymic organ culture was used to investigate the mechanism by which adenosine deaminase (ADA) deficiency causes T-cell immunodeficiency. C57BL/6 fetal thymuses treated with the specific ADA inhibitor 2′-deoxycoformycin exhibited features of the human disease, including accumulation of d...

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Pubblicato in:	J Clin Invest
Autori principali:	Thompson, Linda F., Van De Wiele, C. Justin, Laurent, Aletha B., Hooker, Scott W., Vaughn, James G., Jiang, Hong, Khare, Kamayani, Kellems, Rodney E., Blackburn, Michael R., Hershfield, Michael S., Resta, Regina
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 2000
Soggetti:	Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC301416/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11067867/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI9944
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