Metabolites from apoptotic thymocytes inhibit thymopoiesis in adenosine deaminase–deficient fetal thymic organ cultures

Murine fetal thymic organ culture was used to investigate the mechanism by which adenosine deaminase (ADA) deficiency causes T-cell immunodeficiency. C57BL/6 fetal thymuses treated with the specific ADA inhibitor 2′-deoxycoformycin exhibited features of the human disease, including accumulation of d...

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Bibliografische gegevens

Gepubliceerd in:	J Clin Invest
Hoofdauteurs:	Thompson, Linda F., Van De Wiele, C. Justin, Laurent, Aletha B., Hooker, Scott W., Vaughn, James G., Jiang, Hong, Khare, Kamayani, Kellems, Rodney E., Blackburn, Michael R., Hershfield, Michael S., Resta, Regina
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	American Society for Clinical Investigation 2000
Onderwerpen:	Article
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC301416/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11067867/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI9944
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