BTBR Ob/Ob Mutant Mice Model Progressive Diabetic Nephropathy

There remains a need for robust mouse models of diabetic nephropathy (DN) that mimic key features of advanced human DN. The recently developed mouse strain BTBR with the ob/ob leptin-deficiency mutation develops severe type 2 diabetes, hypercholesterolemia, elevated triglycerides, and insulin resist...

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Detalhes bibliográficos
Main Authors: Hudkins, Kelly L., Pichaiwong, Warangkana, Wietecha, Tomasz, Kowalewska, Jolanta, Banas, Miriam C., Spencer, Min W., Mühlfeld, Anja, Koelling, Mariko, Pippin, Jeffrey W., Shankland, Stuart J., Askari, Bardia, Rabaglia, Mary E., Keller, Mark P., Attie, Alan D., Alpers, Charles E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2010
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3013527/
https://ncbi.nlm.nih.gov/pubmed/20634301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2009121290
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