BTBR Ob/Ob Mutant Mice Model Progressive Diabetic Nephropathy

There remains a need for robust mouse models of diabetic nephropathy (DN) that mimic key features of advanced human DN. The recently developed mouse strain BTBR with the ob/ob leptin-deficiency mutation develops severe type 2 diabetes, hypercholesterolemia, elevated triglycerides, and insulin resist...

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Bibliografski detalji
Glavni autori: Hudkins, Kelly L., Pichaiwong, Warangkana, Wietecha, Tomasz, Kowalewska, Jolanta, Banas, Miriam C., Spencer, Min W., Mühlfeld, Anja, Koelling, Mariko, Pippin, Jeffrey W., Shankland, Stuart J., Askari, Bardia, Rabaglia, Mary E., Keller, Mark P., Attie, Alan D., Alpers, Charles E.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Nephrology 2010
Teme:
Basic Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3013527/
https://ncbi.nlm.nih.gov/pubmed/20634301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2009121290
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