Carnosine Attenuates the Development of both Type 2 Diabetes and Diabetic Nephropathy in BTBR ob/ob Mice

We previously demonstrated that polymorphisms in the carnosinase-1 gene (CNDP1) determine the risk of nephropathy in type 2 diabetic patients. Carnosine, the substrate of the enzyme encoded by this gene, is considered renoprotective and could possibly be used to treat diabetic nephropathy (DN). In t...

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Publicat a:Sci Rep
Autors principals: Albrecht, Thomas, Schilperoort, Maaike, Zhang, Shiqi, Braun, Jana D., Qiu, Jiedong, Rodriguez, Angelica, Pastene, Diego O., Krämer, Bernhard K., Köppel, Hannes, Baelde, Hans, de Heer, Emile, Anna Altomare, Alessandra, Regazzoni, Luca, Denisi, Alessandra, Aldini, Giancarlo, van den Born, Jacob, Yard, Benito A., Hauske, Sibylle J.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5345040/
https://ncbi.nlm.nih.gov/pubmed/28281693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep44492
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