Carnosine Attenuates the Development of both Type 2 Diabetes and Diabetic Nephropathy in BTBR ob/ob Mice

We previously demonstrated that polymorphisms in the carnosinase-1 gene (CNDP1) determine the risk of nephropathy in type 2 diabetic patients. Carnosine, the substrate of the enzyme encoded by this gene, is considered renoprotective and could possibly be used to treat diabetic nephropathy (DN). In t...

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Udgivet i:Sci Rep
Main Authors: Albrecht, Thomas, Schilperoort, Maaike, Zhang, Shiqi, Braun, Jana D., Qiu, Jiedong, Rodriguez, Angelica, Pastene, Diego O., Krämer, Bernhard K., Köppel, Hannes, Baelde, Hans, de Heer, Emile, Anna Altomare, Alessandra, Regazzoni, Luca, Denisi, Alessandra, Aldini, Giancarlo, van den Born, Jacob, Yard, Benito A., Hauske, Sibylle J.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5345040/
https://ncbi.nlm.nih.gov/pubmed/28281693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep44492
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