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Discovery of a novel IKK-β inhibitor by ligand-based virtual screening techniques
Various inflammatory stimuli that activate the nuclear factor kappa B (NF-κB) signaling pathway converge on a serine/threonine kinase that displays a key role in the activation of NF-κB: the I kappa B kinase β (IKK-β). Therefore, IKK-β is considered an interesting target for combating inflammation a...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Elsevier Science Ltd
2011
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3013379/ https://ncbi.nlm.nih.gov/pubmed/21078555 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.10.051 |
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