Discovery of a novel IKK-β inhibitor by ligand-based virtual screening techniques

Various inflammatory stimuli that activate the nuclear factor kappa B (NF-κB) signaling pathway converge on a serine/threonine kinase that displays a key role in the activation of NF-κB: the I kappa B kinase β (IKK-β). Therefore, IKK-β is considered an interesting target for combating inflammation a...

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Main Authors: Noha, Stefan M., Atanasov, Atanas G., Schuster, Daniela, Markt, Patrick, Fakhrudin, Nanang, Heiss, Elke H., Schrammel, Olivia, Rollinger, Judith M., Stuppner, Hermann, Dirsch, Verena M., Wolber, Gerhard
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier Science Ltd 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3013379/
https://ncbi.nlm.nih.gov/pubmed/21078555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.10.051
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