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NF-E2- related factor 2 (Nrf2) is a positive regulator of human bile salt export pump (BSEP) expression

The bile salt export pump (BSEP, ABCB11) is the major determinant of bile salt dependent bile secretion and its deficiency leads to cholestatic liver injury. BSEP/Bsep gene expression is regulated by the nuclear farnesoid X receptor (FXR). However, BSEP expression is retained in the liver of the Fxr...

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Hlavní autoři: Weerachayaphorn, Jittima, Cai, Shi-Ying, Soroka, Carol J., Boyer, James L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3013376/
https://ncbi.nlm.nih.gov/pubmed/19821532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.23151
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