The C-Terminal TDP-43 Fragments Have a High Aggregation Propensity and Harm Neurons by a Dominant-Negative Mechanism

TAR DNA binding protein 43 KD (TDP-43) is an essential gene that regulates gene transcription, mRNA splicing and stability. In amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), two fatal neurodegenerative diseases, TDP-43 is fragmented, generating multiple fragments that include...

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Detalhes bibliográficos
Main Authors: Yang, Chunxing, Tan, Weijia, Whittle, Catheryne, Qiu, Linghua, Cao, Lucheng, Akbarian, Schahram, Xu, Zuoshang
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3013128/
https://ncbi.nlm.nih.gov/pubmed/21209826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015878
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