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The N Termini of TAR DNA-Binding Protein 43 (TDP43) C-Terminal Fragments Influence Degradation, Aggregation Propensity, and Morphology

Fragments of the TAR DNA-binding protein 43 (TDP43) are major components of intracellular aggregates associated with amyotrophic lateral sclerosis and frontotemporal dementia. A variety of C-terminal fragments (CTFs) exist, with distinct N termini; however, little is known regarding their difference...

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Detalhes bibliográficos
Publicado no:Mol Cell Biol
Main Authors: Kasu, Yasar Arfat T., Alemu, Samrawit, Lamari, Angela, Loew, Nicole, Brower, Christopher S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6146831/
https://ncbi.nlm.nih.gov/pubmed/29987190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00243-18
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