Prostaglandin E(2) Activates and Utilizes mTORC2 as a Central Signaling Locus for the Regulation of Mast Cell Chemotaxis and Mediator Release

Prostaglandin (PG) E(2), a potent mediator produced in inflamed tissues, can substantially influence mast cell responses including adhesion to basement membrane proteins, chemotaxis, and chemokine production. However, the signaling pathways by which PGE(2) induces mast cell chemotaxis and chemokine...

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Autores principales: Kuehn, Hye Sun, Jung, Mi-Yeon, Beaven, Michael A., Metcalfe, Dean D., Gilfillan, Alasdair M.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3012997/
https://ncbi.nlm.nih.gov/pubmed/20980255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.164772
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