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Prevention of F-actin assembly switches the response to SCF from chemotaxis to degranulation in human mast cells

Following antigen/IgE-mediated aggregation of high affinity IgE-receptors (FcεRI), mast cells (MCs) degranulate and release inflammatory mediators leading to the induction of allergic reactions including anaphylaxis. Migration of MCs to resident tissues and sites of inflammation is regulated by tiss...

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Detalhes bibliográficos
Main Authors: Smrž, Daniel, Bandara, Geethani, Beaven, Michael A., Metcalfe, Dean D., Gilfillan, Alasdair M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3798040/
https://ncbi.nlm.nih.gov/pubmed/23616175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201243214
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