CD72 negatively regulates KIT-mediated responses in human mast cells

KIT activation, through binding of its ligand, stem cell factor (SCF), is crucial for normal mast cell growth, differentiation, and survival. Furthermore, KIT may also contribute to mast cell homing and cytokine generation. Activating mutations in KIT lead to the dysregulated mast cell growth associ...

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Détails bibliographiques
Auteurs principaux: Kataoka, Tatsuki R., Kumanogoh, Atsushi, Bandara, Geethani, Metcalfe, Dean D., Gilfillan, Alasdair M.
Format: Artigo
Langue:Inglês
Publié: 2010
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2824776/
https://ncbi.nlm.nih.gov/pubmed/20100931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0902450
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