The ARF Tumor Suppressor Regulates Bone Remodeling and Osteosarcoma Development in Mice

The ARF tumor suppressor regulates p53 as well as basic developmental processes independent of p53, including osteoclast activation, by controlling ribosomal biogenesis. Here we provide evidence that ARF is a master regulator of bone remodeling and osteosarcoma (OS) development in mice. Arf(-/-) mic...

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Main Authors: Rauch, Daniel A., Hurchla, Michelle A., Harding, John C., Deng, Hongju, Shea, Lauren K., Eagleton, Mark C., Niewiesk, Stefan, Lairmore, Michael D., Piwnica-Worms, David, Rosol, Thomas J., Weber, Jason D., Ratner, Lee, Weilbaecher, Katherine N.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2010
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3012707/
https://ncbi.nlm.nih.gov/pubmed/21209895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015755
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