The ARF Tumor Suppressor Regulates Bone Remodeling and Osteosarcoma Development in Mice

The ARF tumor suppressor regulates p53 as well as basic developmental processes independent of p53, including osteoclast activation, by controlling ribosomal biogenesis. Here we provide evidence that ARF is a master regulator of bone remodeling and osteosarcoma (OS) development in mice. Arf(-/-) mic...

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Detalhes bibliográficos
Main Authors: Rauch, Daniel A., Hurchla, Michelle A., Harding, John C., Deng, Hongju, Shea, Lauren K., Eagleton, Mark C., Niewiesk, Stefan, Lairmore, Michael D., Piwnica-Worms, David, Rosol, Thomas J., Weber, Jason D., Ratner, Lee, Weilbaecher, Katherine N.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3012707/
https://ncbi.nlm.nih.gov/pubmed/21209895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015755
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