T Cell LFA-1 Engagement Induces HuR-Dependent Cytokine mRNA Stabilization through a Vav-1, Rac1/2, p38MAPK and MKK3 Signaling Cascade

BACKGROUND: Engagement of the β2 integrin, lymphocyte function-associated antigen-1 (LFA-1), results in stabilization of T cell mRNA transcripts containing AU-rich elements (AREs) by inducing rapid nuclear-to-cytosolic translocation of the RNA-stabilizing protein, HuR. However, little is known regar...

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Main Authors: Ramgolam, Vinod S., DeGregorio, Scott D., Rao, Gautham K., Collinge, Mark, Subaran, Sharmila S., Markovic-Plese, Silva, Pardi, Ruggero, Bender, Jeffrey R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3012057/
https://ncbi.nlm.nih.gov/pubmed/21206905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0014450
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