Deacetylation of FoxO by Sirt1 plays an essential role in mediating starvation-induced autophagy in cardiac myocytes

RATIONALE: Autophagy, a bulk degradation process of cytosolic proteins and organelles, is protective during nutrient starvation in cardiomyocytes. However, the underlying signaling mechanism mediating autophagy is not well understood. OBJECTIVE: We investigated the role of FoxOs and its posttranslat...

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Bibliographic Details
Main Authors: Hariharan, Nirmala, Maejima, Yasuhiro, Nakae, Jun, Paik, Jihye, DePinho, Ronald A, Sadoshima, Junichi
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3011986/
https://ncbi.nlm.nih.gov/pubmed/20947830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.110.227371
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