Two-dimensional liquid chromatography system for online top-down mass spectrometry

An online metal-free weak cation exchange-hydrophilic interaction LC/RPLC system has been developed for sensitive, high-throughput top-down MS. Here, we report results for analyzing PTMs of core histones, with a focus on histone H4, using this system. With just ~24 μg on-column of core histones (H4,...

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Autori principali: Tian, Zhixin, Zhao, Rui, Tolić, Nikola, Moore, Ronald J., Stenoien, David L., Robinson, Errol W., Smith, Richard D., Paša-Tolić, Ljiljana
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3010896/
https://ncbi.nlm.nih.gov/pubmed/20879039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pmic.201000367
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