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An integrated top-down and bottom-up strategy for broadly characterizing protein isoforms and modifications
We present an integrated top-down and bottom-up approach that is facilitated by concurrent liquid chromatography-mass spectrometry (LC-MS) analysis and fraction collection for comprehensive high-throughput intact protein profiling. The approach employs high resolution reversed phase (RP) LC separati...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2693490/ https://ncbi.nlm.nih.gov/pubmed/19206473 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/pr800720d |
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