Dissociation of Bimolecular αIIbβ3-Fibrinogen Complex under a Constant Tensile Force

The regulated ability of integrin αIIbβ3 to bind fibrinogen plays a crucial role in platelet aggregation, adhesion, and hemostasis. Employing an optical-trap-based electronic force clamp, we studied the thermodynamics and kinetics of αIIbβ3-fibrinogen bond formation and dissociation under constant u...

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Main Authors: Litvinov, Rustem I., Barsegov, Valeri, Schissler, Andrew J., Fisher, Andrew R., Bennett, Joel S., Weisel, John W., Shuman, Henry
Formato: Artigo
Idioma:Inglês
Publicado: The Biophysical Society 2011
Assuntos:
Protein
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3010843/
https://ncbi.nlm.nih.gov/pubmed/21190668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.11.019
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