Inhibitors of catechol-O-methyltransferase sensitize mice to pain

BACKGROUND AND PURPOSE: Catechol-O-methyltransferase (COMT) inhibitors are used in Parkinson's disease in which pain is an important symptom. COMT polymorphisms modulate pain and opioid analgesia in humans. In rats, COMT inhibitors have been shown to be pro-nociceptive in acute pain models, but...

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Autores principales: Kambur, O, Talka, R, Ansah, OB, Kontinen, VK, Pertovaara, A, Kalso, E, Männistö, PT
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Science Inc 2010
Materias:
Research Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3010567/
https://ncbi.nlm.nih.gov/pubmed/20726980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.00999.x
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