Inhibitors of catechol-O-methyltransferase sensitize mice to pain

BACKGROUND AND PURPOSE: Catechol-O-methyltransferase (COMT) inhibitors are used in Parkinson's disease in which pain is an important symptom. COMT polymorphisms modulate pain and opioid analgesia in humans. In rats, COMT inhibitors have been shown to be pro-nociceptive in acute pain models, but...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Kambur, O, Talka, R, Ansah, OB, Kontinen, VK, Pertovaara, A, Kalso, E, Männistö, PT
Format: Artigo
Langue:Inglês
Publié: Blackwell Science Inc 2010
Sujets:
Research Papers
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3010567/
https://ncbi.nlm.nih.gov/pubmed/20726980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.00999.x
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