Importance of membrane-bound catechol-O-methyltransferase in L-DOPA metabolism: a pharmacokinetic study in two types of Comt gene modified mice

BACKGROUND AND PURPOSE: Catechol-O-methyltransferase (COMT) metabolizes compounds containing catechol structures and has two forms: soluble (S-COMT) and membrane-bound (MB-COMT). Here we report the generation of a mouse line that expresses MB-COMT but not S-COMT. We compared the effects of deleting...

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Bibliographic Details
Main Authors: Käenmäki, M, Tammimäki, A, Garcia-Horsman, JA, Myöhänen, T, Schendzielorz, N, Karayiorgou, M, Gogos, JA, Männistö, PT
Format: Artigo
Language:Inglês
Published: Blackwell Publishing Ltd 2009
Subjects:
Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2807650/
https://ncbi.nlm.nih.gov/pubmed/19930170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2009.00494.x
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