Inhibitors of catechol-O-methyltransferase sensitize mice to pain

BACKGROUND AND PURPOSE: Catechol-O-methyltransferase (COMT) inhibitors are used in Parkinson's disease in which pain is an important symptom. COMT polymorphisms modulate pain and opioid analgesia in humans. In rats, COMT inhibitors have been shown to be pro-nociceptive in acute pain models, but...

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Bibliografische gegevens
Hoofdauteurs: Kambur, O, Talka, R, Ansah, OB, Kontinen, VK, Pertovaara, A, Kalso, E, Männistö, PT
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Blackwell Science Inc 2010
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Research Papers
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3010567/
https://ncbi.nlm.nih.gov/pubmed/20726980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.00999.x
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