Inhibitors of catechol-O-methyltransferase sensitize mice to pain

BACKGROUND AND PURPOSE: Catechol-O-methyltransferase (COMT) inhibitors are used in Parkinson's disease in which pain is an important symptom. COMT polymorphisms modulate pain and opioid analgesia in humans. In rats, COMT inhibitors have been shown to be pro-nociceptive in acute pain models, but...

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Detalhes bibliográficos
Main Authors: Kambur, O, Talka, R, Ansah, OB, Kontinen, VK, Pertovaara, A, Kalso, E, Männistö, PT
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2010
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3010567/
https://ncbi.nlm.nih.gov/pubmed/20726980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.00999.x
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