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Phospholipase D stabilizes HDM2 through an mTORC2/SGK1 pathway
Phosphatidic acid (PA), the primary metabolite of the phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine, has been shown to act as a tumor promoting second messenger in many cancer cell lines. A key target of PA is the mammalian target of rapamycin (mTOR), a serine-threonine kinase tha...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3010228/ https://ncbi.nlm.nih.gov/pubmed/20438709 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2010.04.148 |
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